It was produced by Fred Quimby and directed by William Hanna and Joseph Barbera. The cartoon was animated by Ed Barge, Kenneth Muse and Irven Spence. Musical supervision was done by Scott Bradley, using a version of the theme music “Soldier of Fortune”, from the movie The Girl of the Golden West. The character of Nibbles was voiced by six-year-old Francoise Brun-Cottan.
The Two Mouseketeers won the series’ sixth Academy Award. Such was the cartoon’s success, that Hanna and Barbera created a total of four adventures in the Mouseketeers series; the second, 1954’s Touché, Pussy Cat! received an Oscar nomination.